Explore structural differences between cannabinoid receptors using below NGL Viewer.
A seven transmembrane helices fold of GPCRs was highly conserved during evolution. This allows to obtain high resolution GPCR structures via homology modeling.
An allosteric binding site between transmembrane helices V/VI and VI/VII facing the nonpolar membrane environment.
Jazayeri et al. Nature 2016
Glucagon receptor
Class BAn allosteric binding site located inside the transmembrane core of the receptor.
Hollenstein et al. Nature 2013
CRFR1 receptor
Class BReceptor activation initiated by interactions between peptide agonist and extracellular domain.
Zhang et al. Nature 2017
GLP-1R receptor
Class BA classical activation mechanism involving: Arg-Glu (E/DRY) ionic lock, Lys-Glu lock switch, Tyr toggle switch and Trp transmission switch.
Trzaskowski et al. Curr Med Chem 2012
Rhodopsin
Class AClass C GPCRs include a large extracellular domain called a venus-fly trap domain.
Metabotropic glutamate receptor 5
A first solved class C GPCR structureA first molecular switch between transmembrane helices VI and VII confirmed in class F GPCRs. Wright et al. Nat Commun 2019
SMO receptor
Class F